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STEROID 21-HYDROXYLASE
Descriptors Found:
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DeCS
Descriptor
English
:
Steroid 21-Hydroxylase
Descriptor
Spanish
:
Esteroide 21-Hidroxilasa
Descriptor
Portuguese
:
Esteroide 21-Hidroxilase
Synonyms
English
:
Cytochrome P-450 CYP21
Steroid 21-Monooxygenase
Tree Number:
D08.244.453.915.760
D08.811.682.690.708.170.915.760
D08.811.682.690.708.783.760
D12.776.422.220.453.915.760
Definition
English
:
An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of
steroids
in the presence of molecular
oxygen
and
NADPH-FERRIHEMOPROTEIN REDUCTASE
. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid
hormones
(
CORTICOSTERONE
;
HYDROCORTISONE
). Defects in CYP21 cause congenital adrenal
hyperplasia
(ADRENAL
HYPERPLASIA
, CONGENITAL).
Entry Combination - descr/qualif
English
:
Steroid 21-Hydroxylase
/
deficiency
use
Adrenal Hyperplasia, Congenital
History Note
English
:
2003 (1978)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
23465
Unique Identifier:
D013255
Occurrence in VHL
:
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DeCS
CID-10
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